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Introduction

　　Growing interest in stem cell research has fueled global discussion on the potential of these cells to regenerate diseased or damaged tissues. As a result, there is an ever-increasing need for international cooperation and consultation on stem cell research.

　　

What is Stem Cell International Consultation?

　　Stem cell international consultation refers to discussions, exchanges, and collaborations on stem cell-related policy, ethics, regulations, clinical trials, and standards across multiple countries and regions. It aims to promote the development of responsible stem cell research practices and maximize the benefits of this promising medical technology.

　　

Why is Stem Cell International Consultation Important?

　　Stem cell research is still in its infancy, and there are many uncertainties about its scientific basis, therapeutic potential, and ethical implications. Moreover, different countries and regions have distinct social, cultural, legal, and economic conditions that shape their attitudes and policies toward stem cell research. Therefore, stem cell international consultation is vital for several reasons:

　　

1. To facilitate the sharing of scientific knowledge and technological resources among researchers and clinicians worldwide;
2. To harmonize regulatory frameworks and ethical standards for stem cell research and clinical translation;
3. To ensure patient safety, inform consent, and fair access to stem cell-based therapies;
4. To address cross-border issues such as stem cell tourism, intellectual property, and data sharing;
5. To foster public awareness, education, and engagement on stem cell research and its benefits and risks.

Who Participates in Stem Cell International Consultation?

　　Stem Cell international consultation involves various stakeholders, including government agencies, funding bodies, research institutions, ethics committees, patient organizations, industry partners, and civil society groups. These stakeholders come from different countries and regions and thus bring diverse perspectives, expertise, and priorities to the consultation process.

　　

Examples of Stem Cell International Consultation

　　There are numerous examples of stem cell international consultation that have led to significant outcomes. Here are some of them:

　　

The International Society for Stem Cell Research (ISSCR)

　　Founded in 2002, ISSCR is a global forum for stem cell researchers and professionals who are committed to advancing the field through ethical, rigorous, and transparent practices. ISSCR promotes stem cell international consultation through its annual meetings, policy statements, guidelines, and education programs. ISSCR has developed several renowned guidelines on stem cell research, including:

　　

1. The 2006 Guidelines for the Clinical Translation of Stem Cells;
2. The 2016 Guidelines for Stem Cell Research and Clinical Translation;
3. The 2021 Guidelines for Stem Cell-Based Interventions for COVID-19.

The Global Alliance for iPSC Therapies (GAiT)

　　GAiT is a non-profit organization established in 2014 to accelerate the development and commercialization of induced pluripotent stem cell (iPSC) therapies, which can be derived from adult cells and have great potential to treat various diseases. GAiT coordinates stem cell international consultation and collaboration among academia, industry, regulators, and patient groups to overcome technical, regulatory, and ethical barriers to iPSC therapy development. GAiT aims to create a global network of iPSC banks, GMP facilities, clinical trial centers, and regulatory authorities.

　　

The Human Genome Editing Initiative (HGEI)

　　The HGEI is an international effort launched in 2018 to develop a framework for the responsible use of genome editing technologies, including CRISPR-Cas9, in human germline cells, embryos, and gametes. The HGEI involves experts from the US, UK, China, Japan, Canada, and many other countries and aims to promote international dialogue and consensus on ethical, social, and legal issues related to human genome editing. The HGEI has produced several reports and recommendations on human genome editing, including:

　　

1. The 2020 International Commission Report on Heritable Human Genome Editing;
2. The 2021 Global Forum Report on Human Genome Editing Governance.

Conclusion

　　Stem cell international consultation is a critical component of the global effort to harness the potential of stem cell research for human health and wellbeing. By collaborating across borders and disciplines, stakeholders can overcome challenges and maximize opportunities of stem cell-based therapies in a responsible and equitable manner. Governments, funding bodies, research institutions, and civil society organizations should support and participate in stem cell international consultation efforts to ensure that the benefits of stem cell research are shared by all.