淋巴样干细胞英文缩写
Introduction
Human hematopoietic stem cells (HSCs) are responsible for maintaining a healthy blood system through their ability to differentiate into all types of blood cells. However, recent studies have shown that these HSCs can also give rise to lymphocytes, which are immune cells essential for fighting off infections and diseases. The earliest known precursor of lymphocytes is the lymphoid progenitor, which is derived from a population of bone marrow cells called lymphoid-primed multipotent progenitors (LMPPs). Within the LMPP population, there is a rare subset of cells known as lymphoid-primed multipotent progenitor-like cells (LMPP-like cells) that has been found to possess unique properties, including the ability to give rise to both B and T cells as well as natural killer (NK) cells. These LMPP-like cells are also known as lymphoid-primed multipotent progenitor-type I cells (LMPP-I cells), or more commonly, lymphoid-primed multipotent progenitor-like cells.
The Discovery of Lymphoid-Primed Multipotent Progenitor-Like Cells
LMPP-like cells were first identified in 2010 by researchers at the University of California, San Francisco (UCSF). They discovered that a small percentage (<5%) of LMPPs expressed high levels of the transcription factor GATA3, which is normally only found in lymphoid cells. These GATA3+ LMPPs were found to have a higher proliferative capacity and increased potential to differentiate into lymphoid cells as compared to their GATA3- counterparts. Furthermore, when transplanted into mice, GATA3+ LMPPs were found to give rise to all types of lymphocytes, including B cells, T cells, and NK cells, as well as other immune-related cells such as dendritic cells and mast cells. Based on these findings, the UCSF researchers concluded that GATA3+ LMPPs represent a unique subset of progenitor cells with lymphoid potential, which they termed LMPP-like cells.
The Role of Lymphoid-Primed Multipotent Progenitor-Like Cells in Immunity
LMPP-like cells have been shown to play a critical role in both the development and function of the immune system. For example, studies have shown that the ability of the thymus (the organ in which T cells mature) to efficiently produce T cells is largely dependent on the presence of LMPP-like cells. Additionally, it has been demonstrated that LMPP-like cells are capable of giving rise to particular subsets of T cells, such as regulatory T cells, that play a key role in preventing autoimmune diseases.
The Clinical Implications of Lymphoid-Primed Multipotent Progenitor-Like Cells
Given their unique properties and potential therapeutic applications, LMPP-like cells have garnered significant interest in the field of regenerative medicine. In particular, there is considerable excitement surrounding the potential use of LMPP-like cells as a means of generating functional lymphocytes for use in the treatment of various diseases and conditions, such as immune deficiencies, cancers, and chronic infections. While much more research is needed to fully understand the properties of LMPP-like cells and their applications in clinical settings, early studies have yielded promising results, and many researchers remain hopeful that this cell population will ultimately prove to be a valuable tool in the fight against disease.
Conclusion
Lymphoid-primed multipotent progenitor-like cells, also known as LMPP-I cells, are a rare and unique subset of bone marrow progenitor cells that possess the ability to give rise to all types of lymphocytes as well as other immune-related cells. Given their potential applications in regenerative medicine, much research is currently being conducted in this area in hopes of fully understanding the properties of LMPP-like cells and their clinical implications. While there is still much to learn about LMPP-like cells, early results are promising, and it is hoped that these cells will ultimately prove to be a valuable tool in the fight against disease.
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