自体造血干细胞移植英文

　　

1. Introduction

　　Autologous hematopoietic stem cell transplantation (AHSCT) is a medical procedure where patients receive their own blood stem cells after undergoing high-dose chemotherapy or radiation therapy. The purpose of AHSCT is to replace damaged bone marrow or blood cells with healthy ones, essentially resetting the patient’s immune system.

　　

2. The Procedure

　　The process of AHSCT involves several stages:

　　

　　

1. Mobilization: The patient receives medication that stimulates the production and release of stem cells from the bone marrow into the bloodstream.

　　

2. Collection: The stem cells are collected from the patient through a process called apheresis, which involves removing blood from the patient and separating out the stem cells using a machine.

　　

3. Conditioning: The patient undergoes high-dose chemotherapy or radiation therapy to destroy any remaining cancer cells and suppress the immune system in preparation for the stem cell transplant.

　　

4. Transplantation: The patient receives a transfusion of their own previously collected stem cells, which migrate to the bone marrow and begin to produce new blood cells.

　　

　　

3. Indications

　　AHSCT is primarily used as a treatment option for patients with blood cancers, such as leukemia, lymphoma, and multiple myeloma. It may also be used for other diseases, including autoimmune disorders and some solid tumors.

　　

4. Benefits and Risks

　　The benefits of AHSCT include a higher likelihood of achieving remission for patients with blood cancers and autoimmune diseases, as well as a lower risk of rejection or graft versus host disease (GVHD) since the patient’s own cells are used. However, there are also risks associated with the procedure, such as infection, bleeding, and organ damage from the high-dose chemotherapy or radiation therapy.

　　

5. Recovery and Follow-Up

　　After undergoing AHSCT, patients typically stay in the hospital for several weeks to monitor their recovery and manage any complications. Recovery can take several months, during which time the patient is at increased risk of infection due to the suppressed immune system. Patients also require ongoing follow-up care to monitor their progress and address any long-term side effects.

　　

6. Conclusion

　　AHSCT is a complex medical procedure that offers a potentially curative treatment option for patients with blood cancers and autoimmune disorders. While it does carry risks, these are offset by the potential benefits, and many patients have found success with the procedure. As with any medical treatment, it is important for patients and their healthcare providers to carefully weigh the risks and benefits before deciding on a course of action.